Synthesis and evaluation of selective anticholinergics phencynonate hydrochloride

摘要

series of alkyl amines, substituted amino-ethers and esters were synthesized. Preliminary pharmacological resutls showed that most of them exhibited potnet icentral anticholinergic activities. Those with a substituted cycloamine show higher bioactivities than those with a substituted chain amine. In ethers or esters, when the substituted groups are phenyl, cyclopentyl or cyclohexyl, then the compounds show greater activity. In some stereosiomers and optical isomers, exist significantly differnet anticholinergic activity. Through many years chemical and biological work, Phencynonate hydrochloride, a selective anticholinergiecs, was found. It had been approved by the authority for the protection of motion diseases.