A new mathematical model of the myelinated nerve fiber was applied to the study of conduction behavior. This model represents the myelinated nerve fiber as a multiaxial equivalent electric circuit incorporating separate intra-axonal, periaxonal and extra-axonal longitudinal conductive pathways with independent representations of the myelin sheath versus the underlying axolemmal membrane. A detailed anatomical representation of the node is included, with the periaxonal space extending to the nodal compartment. Both amphibian and mammalian nerve fibers were modeled. Model results show a physiological conduction velocity of 57.6 m/s for 17.5- mu m-diameter mammalian nerve fiber at 37 degrees C with a change in conduction velocity versus temperature closely correlated to experimental findings. The periaxonal space width and the axon radius in the paranodal region are shown to have a strong influence on conduction velocity.
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机译:一种新的有髓神经纤维的数学模型被用于研究传导行为。该模型将有髓神经纤维表示为多轴等效电路,其中包含独立的轴突内,轴突和轴外纵向传导路径,并独立代表髓鞘相对于下面的轴突膜。包括结节的详细解剖图,其轴旁空间延伸至淋巴室。两栖动物和哺乳动物的神经纤维均已建模。模型结果显示,在37摄氏度下,直径为17.5微米的哺乳动物神经纤维的生理传导速度为57.6 m / s,传导速度与温度的变化与实验结果密切相关。结节旁区域的轴突间隙宽度和轴突半径显示出对传导速度的强烈影响。
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