Biomimetic Synthesis of Silicon-Substituted HA on a Titanium Substrate

摘要

Since silicon plays an important part in physiological processes underlying the growth and transformations of bone tissue and cartilage, the study of the properties of silicon-substituted hydroxyapatite (Si-HA) synthesized under near-physiological conditions is an important and promising physicochemical issue. An important point in biomimetic synthesis is to optimize conditions for the preparation of fine powders with a high resorption rate, biocompatible with the human body. In this work was to study the feasibility of producing coatings on titanium substrates by applying silicate-ion-modified calcium orthophosphates synthesized from simulated body fluid (SBF). We have demonstrated that samples synthesized from an SBF solution with different concentrations of silicon ions are single-phase and consist of siliconcontaining HA. The nature of the precursor has no effect on the structure of HA. Analysis of the surface characteristics and morphology of the silicon-modified phosphate coatings obtained indicates that more complete Si-HA deposition on the surface of titanium substrates occurs on etched samples during the first three days of holding in a model solution. After exposure of titanium substrates to an HIB, further crystal growth and surface regeneration are possible. The present results can be useful in producing promising materials for orthopedics and transplantology.