Smart antibacterial surfaces fabricated via layer-by-layer deposition and host-guest interaction

摘要

A multifunctional antibacterial surface with bacterial release capability and regenerability was fabricated via a simple and versatile strategy with broad applicability. This strategy exploits the combined advantageous features of LBL deposition and supramolecular host-guest interactions into a single system, eliminating the drawbacks of traditional approaches for fabricating antibacterial surfaces. The substrate-independent characteristic of LBL technique facilities the broad applicability of coating virtually any substrate regardless of surface properties, ranging from metals and oxides to synthetic polymers. Additionally, the noncovalent nature of supramolecular host-guest interactions provides the flexibility to allow the easy removal of dead bacteria and debris and regenerate the surfaces by introduction of SDS to dissociate the host/guest pairs. Considering these attributes of generality and versatility, this work may serve as the foundation for a new methodology for the engineering of multifunctional antibacterial surfaces for a variety of practical applications in the biomedical and biotechnology fields.