Wnt7a-Releasing Hydrogel for Enhancing Local Skeletal Muscle Regeneration

摘要

A synthetic hydrogel that enables local delivery of Wnt7a for treating skeletal muscle injuries and diseases, where direct injection is not applicable, has been engineered. Wnt7a released from the engineered hydrogel retains biological activity. This system is currently being evaluated for co-delivering Wnt7a and muscle stem cells to treat volumetric muscle loss.