Thrombogenicity Evaluation of Medical Device Materials with an In Vitro Flow Loop System Under Varying Flow Conditions

摘要

The data suggest that flow rate substantially impacts the thrombogenicity differentiation of biomaterials. For the current system, 200 mL/min provided the best distinction between the materials. The variability in thrombosis for in vitro blood flow loops may be decreased by using controlled donor-specific heparin concentrations and system-specific flow rates. The higher hemolysis levels produced at 300 mL/min may contribute to non-material mediated coagulation and therefore a flow rate at or above this level may not be appropriate for examining device thrombogenicity in this system.