Multiarm Avidin Nanoconstruct as a Cationic Carrier for Intra-cartilage Drug Delivery

摘要

We designed a new cationic protein carrier by conjugating 8-arm PEGs to Avidin creating a branched nanoconstruct with enhanced drug loading capacity for targeting negatively charged cartilage. Ongoing work includes conjugation of Dex and KGN to Avidin multiarm-PEG followed by evaluation of their efficacy using cytokine challenged in-vitro cartilage culture.