Synthetic β-cells for fusion-mediated dynamic insulin secretion

摘要

To conclude, we have demonstrated that the synthetic AβCs could recapitulate the key functions of β-cells, including sensing glucose levels, internally transducing signals and dynamically secreting insulin via vesicle fusion. Albeit many gaps remain between biomimetic assemblies and natural cells, the described design principle lay the groundwork for developing the next generation of artificial cells with the goal of achieving long-term replacement therapy to correct for cell function deficiency.