Polymer Scaffolds for Early Detection and Vaccination Against Metastatic Breast Cancer

摘要

1. Microporous PCL scaffolds recruit metastatic E0771 tumor cells in vivo, which support their potential for early detection of metastatic cells. 2. The scaffold-based allogeneic tumor vaccine reduced tumor burden and incidence in the E0771 -Br2 mouse tumor model in a prophylactic setting. 3. The vaccine will be further investigated for its efficacy as a therapeutic against metastasis at early and late time points following primary tumor resection.