Selective targeting of small-molecule drugs to specific locations in the body is critical for disease therapy, especially in cases where therapy is highly toxic or falls within a narrow therapeutic window. Bioorthogonal click chemistry provides the specificity and selectivity for targeting of therapeutics to specific areas of the body through the use of refillable drug delivery depots. Click-mediated targeting excibits a high degree of specificity for the target sites and the targeting could be repeated over a period of four months through multiple administrations. These studies demonstrate the potential of click-mediated refillable systems for targeting for drugs in a wide range of applications, including in cancer, ischemia and infarct and in infections.
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