A Wireless Optoelectronic Neuroscience Platform for Chronic Fluorescence Sensing in Freely Behaving Rodents

摘要

We present a new head mountable wireless fiber biophotometry microsystem conceived to detect fluorescent signal fluctuations correlated with neuronal activity. The proposed system incorporates all aspects of a conventional tethered fiber-based biophotometry system encompassed into a wireless microsystem. The interface includes an LED as excitation light source, a custom designed CMOS biosensor, a multimode fiber, a microcontroller (MCU), and a wireless data transceiver enclosed within a 3D-printed, small and light weight, plastic housing. Precisely, the system incorporates a new optoelectronic biosensor merging two individual building blocks, namely a low-noise sensing front-end and a 2^nd order continuous-time ΣΔ modulator (CTSDM), into a single module for enabling high-sensitivity and high energy-efficiency photo-sensing. The proposed CMOS biosensor is implemented in a 0.18-μm CMOS technology, consuming 41 μW from a 1.8-V supply voltage, while achieving a peak dynamic range of 86 dB over a 50-Hz input bandwidth at a 20-kS/s sampling rate. This new interface opens new avenues for conducting in-vivo experiments with live animals.