Bilayered Scaffolds (Loofah/PLLA/cellulose/chitin) for Osteochondral Defect Repair: Synthesis and In-vitro #Characterization

摘要

Conclusions: Tissue engineered osteochondral grafts must be designed to repair and integrate both the injured cartilage and the subchondral bone (1). Adhesion of cells to the surface of a biomaterial is one of the major factors mediating its biocompatibility. Experimental methods to determine cell adhesion rely on morphological and biomechanical approaches. While porosity of scaffold mimics the microstructure of cancellous bone or cartilage the surface properties of biomaterials play a major role in cellular interactions, such as cell adhesion, infiltration and proliferation (2,3). This study shows that cultivation of chondrocytes and osteoblast on loofah based scaffolds may have potential for applications in the field of cartilage tissue engineering to repair osteochondral defects. Further studies are required to use these constructs to diminish complications caused by currently available.