Polydopamine Nanoparticle Size Optimization for Smart Drug Delivery Applications

摘要

Conclusions: A series of PDA NP synthesis experiments were conducted with the Design Expert 8.0 factorial analysis software. The results showed that the size distribution of PDA NPs was mainly based on the initial DA concentration and pH of the synthesis reactions. In addition, PDA NPs with a size of interest could be formed using the size-factor relation equation generated from the factorial simulation analysis. As a result, these data can provide researchers to optimize PDA NP synthesis reactions to have more standardized PDA NP formulations for the development of PDA NP-based imaging and drug delivery platforms.