Smart Heparin Transcutaneous Patch

摘要

In conclusion, we developed a thrombin-responsive patch for auto-regulation of blood coagulation by integrating TR-HAHP matrix with MN-array. The thrombin-cleavable peptide unit enabled thrombin-specific activation of drug release from the system with a rate highly dependent on the thrombin concentration. More importantly, it enabled feedback-controlled anticoagulation therapy with minimized risk of over- or under-dosage. The in vivo studies in a thrombolytic challenge model demonstrated effective protection from acute pulmonary thromboembolism in a long-lasting fashion.