Conclusions: The pAAZ-grafted surfaces effectively resist protein adsorption from undiluted human blood serum and plasma. Moreover, the polymers can highly resist adhesion from endothelial cells, and prevent long term biofilm formation from P. aeruginosa and S. epidermidis. Not only such materials can be coated on the biomedical device surfaces to prevent biofouling, they can also be utilized to create or coat nanoparticles (e.g., nanogels, gold nanoparticles) for a variety of applications such as targeted drug delivery for cancer treatment.
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