Osteoblast Functions of Bioactive 3D Printed Interconnected Porous Ti-6Al-4V Mesh Structures

摘要

Conclusions: The combination of bioactive titania and interconnected porous architecture of titanium alloy mesh structures was conducive to osteoblast functions including adhesion, proliferation, mineralization, and synthesis of proteins (actin, vinculin, and fibronectin). Pre-osteoblasts strongly adhered to the struts and formed a sheet-like morphology on as-fabricated surface, whereas, on bioactive titania-modified surface, the filopodia of cells interacted with micro pores and nanopores on the surface by promoting strong bonding with the surface.