Pharmacokinetic modeling-exploring PFOA drinking water data and serum PFOA levels

摘要

An individual's serum PFOA concentration is a product of a complex interaction of individual pharmacokinetic parameters and historical exposures. While drinking water is the most well characterized PFOA exposure pathway, past non-drinking water exposures may be important determinants of current serum PFOA concentrations. A novel model incorporating in vitro and in vivo extrapolation-derived parameters into a PBPK model successfully describes human PFOA serum kinetics. This model provides new information to improve risk assessment of human exposure to PFOA and inform decisions about exposure mitigation. Additionally, the model shows that past exposures are important for predicting current PFOA serum concentrations and that measured drinking water concentrations may not be ideal predictors of serum PFOA concentration.