SERS detection and analysis of a single DNA oligomer using a single gold nanoparticle dimer

摘要

This paper reports surface-enhanced Raman spectroscopy (SERS) analysis of a single DNA oligomer toward SERS-based reliable DNA sequencing using a single gold nanoparticle dimer. Due to the Raman enhancing hotspot with 1-nm nanogap in the single dimer, for the first time, the single oligomer detection and analysis was demonstrated. The dimer identified the several bases and backbone components of the single DNA oligomer. The dynamics of the single oligomer could be analyzed. The oligomer was trapped and stayed at the nanogap hotspot, and fluctuated with rotation.