Electrical resistance in inhomogeneous samples during electroporation

摘要

In electrochemotherapy (ECT), electric field is applied by means of needle pairs to the tumor tissue in order to permeabilize cell membranes and, as a consequence, enhance the effects of chemotherapeutic drugs. The target tissue is not homogeneous and the electric field, generated by the needle pairs, is strongly affected by the specific electrical characteristics of different tissues. This paper analyzes the effect of tissue in homogeneity by means of numerical models and suitable experiments.