Patterned deposited nanofibers/microparticles in electrospinning technique to fabricate 3D highly porous scaffold with dual pore size for bone tissue engineering application

摘要

An ideal tissue-engineering scaffold should resemble the ECM both in nanofiberous structure and components. Electrospinnig is a valuable technique to crate nanofiberous mats. But these electrospoun structures are very compact with small pore size which inhibits cell infiltration. In this work we performed a new technique in the use of electrospinning method to fabricate 3D highly porous structure with enhanced pore size compared to conventional compact elctrospoun mats. Morphological properties, pore size and porosity and enhanced cellular behaviour on the new-designed structure is verified and compared to those of conventional electrospoun structure.