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Poverty and the emergence of tuberculosis: An agent-based modelling approach

机译:贫困与结核病的出现:一种基于病原体的建模方法

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Tuberculosis has been observed to thrive in conditions of poverty and there has been a long history of documented linkage between tuberculosis and poverty at the society and community level. This paper utilizes an agent-based model to incorporate three aspects of the conditions faced by the economically poorer and vulnerable individuals. The three aspects considered in the paper include undernutrition, poor living conditions (overcrowding, inadequate ventilation) and access to adequate health care facilities. The paper aims to understand the effects of poor living conditions on the emergence of latent tuberculosis infection among individuals exposed to the disease. Also, we consider the effect of undernutrition on the immune system response to control the progression from the latent tuberculosis infection to the active tuberculosis disease. Finally, the paper studies the effect on adequate access to proper health care as a factor on the emergence of tuberculosis. The results obtained indicate that malnutrition coupled with limited access to adequate health care increases the risk of emergence of the active tuberculosis disease and also that inadequate ventilation increases the risk of emergence of the latent tuberculosis infection (LTBI).
机译:有人指出,在贫困状况下,结核病很盛行,在社会和社区一级,结核病与贫困之间的联系已有悠久的历史记载。本文利用基于主体的模型来纳入经济上较贫穷和脆弱人群所面临的条件的三个方面。本文考虑的三个方面包括营养不良,生活条件差(人满为患,通风不足)和获得足够的医疗保健设施。本文旨在了解生活条件恶劣对暴露于该疾病的个体中潜伏性结核感染的影响。此外,我们考虑营养不足对免疫系统反应的影响,以控制从潜伏性肺结核感染向活动性肺结核疾病的发展。最后,本文研究了对充分获得适当医疗保健的影响,这是结核病出现的一个因素。获得的结果表明,营养不良加上有限的获得充分医疗保健的机会,增加了活动性结核病出现的风险,并且通风不足也增加了潜伏性结核感染(LTBI)出现的风险。

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