Multi-Functional Nanoparticle Development for Glycocalyx Heparan Sulfate Regeneration on Cultured Endothelial Cells

摘要

The nano-scale gold carriers function as a potential candidate for drug delivery and imaging for GCX regenerative applications. PEGylation decreased nonspecific cellular uptake and the degradation models provide a discontinuity in the GCX layer that allow the nanoparticles to passively target areas of interest. Delivery of the HS related therapeutics boosted recovery of the damaged GAGs and restored the barrier function of GCX. The modular aspect of the gold nanoparticles allow for easy translation to the other components of the GCX for a more comprehensive, generalized therapeutic mixture that can target all of the GAGs. The recovery of the GCX can prevent the initiation of atherosclerotic plaque development and lower cardiovascular disease related deaths.