PLGA/Chitosan based Composite Microspheres for Drug Delivery

摘要

Both natural and synthetic biodegradable polymers are ideal for drug delivery systems as compared to non-degradable polymers. PLGA as a hydrophobic polymer is an ideal drug carrier, but its incompatible surface property and high degradation rate sometimes make it unacceptable. The combination of hydrophobic and hydrophilic systems is a promising strategy to overcome this unacceptability. Similar to this concept in this study we proposed a design to synthesize composite microspheres consisting of two biodegradable polymers (PLGA and chitosan) and one biodegradable therapeutic (MgG). This study suggests that MgG encapsulated PLGA/LMWC microspheres possess good potential for efficient and safer drug delivery. Drug loading efficiency, in vitro drug release study, and cell viability test will be performed in future.