Sustained Release of Short Peptides Using Guest-Host Complex Formation in Injectable Hydrogels

摘要

Both gel formulation and payload chemistry can be leveraged to provide sustained release of short peptides in self-assembled hyaluronic acid hydrogels. Cyclodextrin content and peptide chemistry dramatically alter micro-scale and bulk kinetics of short peptides, suggesting polymer affinity is a powerful tool for controlling small molecule release from these systems. Towards translational therapies, APP-IP sustained release from these gels could lead to improved cardiac outcomes. Ongoing studies in rat models of MI will assess therapeutic benefit of injectable gels designed for the sustained release of APP-IP.