Determining the Specificity of a Multivalent Polymeric Antigen-Specific Immunotherapy for Multiple Sclerosis

摘要

SAgA molecules bind Raji B cells in a specific manner and conjugated peptides (LABL and PLP) increase binding. Specificity is primarily attributed to PLP. Ongoing studies are exploring the binding specificity of SAgAs with other cell types known to be involved in the immunological synapse, including mixed murine splenocyte populations.