Temporal fluctuation analysis of tremor signal in Parkinson's disease and Essential tremor subjects

摘要

Tremor is a common symptom shared in both Parkinson's disease (PD) and Essential tremor (ET) subjects. The differential diagnosis of PD and ET tremor is important since the treatment depends on specific medication. A novel feature was developed based on a hypothesis stating that the tremor of PD subject has a larger fluctuation while performing resting task than action task. Tremor signal was collected using a gyroscope sensor attached to subject's finger. The angular velocity signal was analyzed by transforming a one-dimensional to two-dimensional signal based on relation of different units of time-delay. The tremor fluctuation was defined as the area of 95% confidence ellipse covering the two-dimensional signal. Experimenting with 32 PD and 20 ET subjects, a ratio of fluctuation of resting to kinetic task can be a sensitive feature to discriminate PD from ET with 100% accuracy.