Soft microfluidic neural probes for wireless drug delivery in freely behaving mice

摘要

We present ultrathin, soft microfluidic neural probes with wireless drug delivery capability that can be injected precisely in the deep brain tissue. These probes permit targeted, wireless, spatiotemporal control of pharmacological manipulation in freely behaving mice. Because of the flexible, wireless nature of this probe, it is minimally invasive and has potential for broad applications in neuroscience as well as clinical medicine.