OpenGL-based interactive graphic treatment planning interface realization for transcranial focused ultrasound brain-blood barrier opening

摘要

Focused ultrasound (FUS) has been discovered its utility in targeted increase blood-to-brain permeability in the brain and capable of enhancing drug delivery for CNS disease treatment. To achieve successful treatment, the overall FUS exposure process relies on employing a sophisticated treatment planning procedure to precisely target the ultrasound energy to the aim and compensate the skull-induced energy loss and focal beam distortion issues. An interactive interface is therefore essential to be developed prior to the clinical application of the FUS brain treatment. In this study, we propose the development of an OpenGL-based interactive graphic interface realization for treatment planning of FUS-induced brain treatment. We demonstrate the usefulness of the proposed interface in providing functions including interactive 3D anatomical demonstration, co-registration, and FUS pattern prediction and simulation.