Control of the blood glucose level in diabetic patient using predictive controller and delay differential equation

摘要

Diabetes is known as the sixth leading cause of death in the world leading to kidney and cardiovascular diseases as well. As a result, controlling the disease is of particular importance. To control blood glucose level in diabetes mellitus type I, insulin must be injected into the body. This injection must be strictly controlled - any excessive increase in insulin injection can cause human death. Various controllers have been introduced to control diabetes type I with their own disadvantages. Diabetic patient model used in previous methods is not in compliance with physiological data, uncertainties are not considered in the model, or the controller has a very limited range of stability. In this paper, a Nonlinear Model Predictive Controller is introduced which not only resolves previous problems like lack of consideration of model uncertainty, sharp drop in blood glucose, and low stability, but also specifies insulin injection dosage based on blood glucose level momentarily so that.