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Experimental and Computational Investigation of Activity of Osteogenic BMP-2 Peptide in Amphiphilic PEG Hydrogels

机译:两亲性PEG水凝胶中成骨BMP-2肽活性的实验和计算研究

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摘要

The significantly lower activity of peptides in engineered matrices can be traced back to peptide aggregation, leading to lower bioactivity in synthetic hydrogels. Further, peptide aggregation increased nonspecific cell interaction, membrane rupture, and peptide uptake by the cells (data not shown).
机译:工程基质中肽的明显较低的活性可以追溯到肽聚集,从而导致合成水凝胶的生物活性较低。此外,肽聚集增加了非特异性细胞相互作用,膜破裂和细胞对肽的摄取(数据未显示)。

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