Screening of the Biological Interactions of Methacrylic Acid Polymers

摘要

MAA influenced cell behavior, protein interactions and tissue reactions in a composition-dependent manner to promote increased in vivo vascularization. MAA copolymers altered the behavior of dTHP1 cells to express increased angiogenic and inflammatory genes. MAA copolymer beads adsorbed different plasma proteins which resulted in lower complement activation. These phenomena may alter the wound healing environment in vivo causing the resulting histological features. Future studies will assess the in vivo reactions in further detail.