Hyaluronan-Fibrin Gel System for Cartilage-Mediated Bone Regeneration

摘要

Scaffold systems designed to provide the necessary micro-environment is essential for successful tissue regeneration. Through this study, we have created a novel IPN like gel system with variable stiffness suitable to support the stages of cartilage-mediated bone regeneration. The developed gel system combined with a weight-bearing scaffold and enriched human bone marrow aspirate, we propose to develop a novel strategy for segmental bone defect repair via endochondral ossification route.