Protein Adsorption and Affects on Platelet Adhesion and Bacterial Adhesion on Submicron Textured Biomaterial Surfaces

摘要

The long term use of synthetic polymeric biomaterials in blood-contacting devices is complicated by the potential for thromboembolic events and microbial infection. Recently, the use of topographical changes for controlling these biological responses is becoming more prevalent. Our previous data have shown that submicron textured polyurethane biomaterial surfaces could reduce both platelet adhesion and bacterial adhesion, thereby inhibiting thrombosis and microbial infection. To better understand the role of topography in response to blood, in this study, we further studied the protein adsorption and its effect on platelet and bacterial adhesion on textured surfaces since protein adsorption is a critical early event during the interaction of blood with implanted biomaterials.