Injectable chitosan hydrogels with tailored degradation and release properties for localized biomolecule delivery

摘要

The study demonstrated the feasibility of developing enzymatically crosslinkable hydrogels capable of supporting localized bone formation in the presence of rhBMP-2. The gel degradation and protein release can be further tailored via polymer modification. Due to the chemical versatility, these gels have the potential to serve as a carrier platform with tunable degradation and release kinetics for localized drug/growth factor delivery.