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Design and Surface-Modification of Poly(Propylene Fumarate) Scaffolds for Mesenchymal Stem Cell Attachment and Differentiation

机译:富马酸丙二醇酯支架的设计和表面修饰,用于间充质干细胞的附着和分化

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Results showed successful fabrication of both RPA and CPA scaffolds with actual porosities near the desired percentage. Additionally, PPF scaffolds modified at the surface with ECM proteins increase adhesion and spreading of cells indicating that modified scaffolds can be used to facilitate MSC adhesion and subsequent 3D culture. These results will be used in future studies to investigate how the incorporation of growth factors at the PPF surface influences the differentiation of attached MSCs.
机译:结果表明,RPA和CPA支架均成功制造,实际孔隙率接近所需百分比。另外,在表面用ECM蛋白修饰的PPF支架增加了细胞的粘附和扩散,表明修饰的支架可用于促进MSC粘附和随后的3D培养。这些结果将用于将来的研究中,以研究生长因子在PPF表面的掺入如何影响附着的MSC的分化。

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