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Test-retest Reliability of Functional Connectivity and Graph Metrics in the Resting Brain Network

机译:测试 - 在静脑网络中的功能连接和图形度量的测试重新测试

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The combination of graph theoretical approaches and neuroimaging data provides a powerful way to explore the characteristics of brain network. Recently, the temporal variability of spontaneous brain activity and functional connectivity has attracted wide attention. Thus, it is essential to evaluate the reliability of functional network connectivity and properties from the dynamic perspective. However, previous test-retest (TRT) studies have explored this reliability with a static point of view. In this study, using a large rs-fMRI dataset from Human Connectome Project (HCP), we investigated TRT reliability of functional connectivity and graph metrics derived from the most commonly used method - sliding window at three time intervals (short: 72 seconds, middle: 15 minutes and long: >24 hours). The results revealed that reliable connectivities and related brain regions are mainly distributed in primary cortex, such as visual area and sensorimotor area and default mode network. Notably, connectivity strength and global efficiency have better reliability than other metrics. Finally, short scan time interval and long scan duration can increase the TRT reliability of metrics. Findings of present study provide important guidance for searching reliable network markers in future research.
机译:图形理论方法和神经影像数据的组合提供了一种探索脑网络特性的有力方法。最近,自发性大脑活动和功能性连接的时间变异引起了广泛的关注。因此,必须评估动态视角的功能网络连接和特性的可靠性。然而,以前的测试 - 重新测试(TRT)研究通过静态的观点探讨了这种可靠性。在本研究中,使用来自人类连接项目(HCP)的大型RS-FMRI数据集(HCP),我们调查了TRT可靠性的功能连接和图形指标,并以三次间隔从最常用的方法滑动窗口导出(短:72秒,中间:15分钟和长期:> 24小时)。结果表明,可靠的连接性和相关脑区主要分布在原发性皮层中,例如视觉区域和传感器区域和默认模式网络。值得注意的是,连接力和全球效率比其他指标更具可靠性。最后,短扫描时间间隔和长扫描持续时间可以提高度量标准的特技可靠性。目前研究的调查结果为在未来的研究中寻找可靠的网络标记提供了重要指导。

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