Background: Some work environments can greatly affect human health especially in cases where workers are exposed to both detrimental conditions and noxious agents in the work-place and also harmful environmental and lifestyle factors. Aims: Because of the potential human toxicities of phthalates there was realized a cohort study in environmentally exposed group of individuals in plastic industry. Methods: AQM60 Environmental Station, DustTrak DRX8533 and VaisalaWXT520 was used for the air quality detection. Urine were collected from 22 individuals, analyzed for parent phthalate compounds and hthalate metabolites using HPLC MS/MS. Personal questionnaire, spirometry and anthropometry were examined by standard methods. Results: CO, NOx, SO2, CO2, VOC, PM1, PM2.5, PM10 and total dust were detected in the production hall at higher levels. Symptoms of chronic obstructive pulmonary disease (4.5%) and chronic mucopurulent bronchitis (50.0%) were detected. There was a tendency towards increased for man and women in BMI (26.8; 28.2), FMI (6.2; 11.0), FFMI (20.4; 17.21) and WHR (0.96; 0.89). All individuals had MEP - monoethyl phthalate, MBP - monobuthyl phthalate, MEHP - monoethylhexyl phthalate and MiNP - monoisononyl phthalate in their urine samples, suggesting widespread phthalate exposure. Tolerable daily intake (TDI) was exceeded in di-2-ethylhexyl phthalate DEHP (59 μg/kg/day). DiNP (diisononyl phthalate) was higher in individuals with airways diseases (7.24 μg/kg/day) than others. Conclusions: Unsatisfactory working conditions (combination of higher temperature, low relative humidity, presence of phthalates) may have a negative impact on human health. We suppose on potential effect of phthalate exposure as a causative factor for presence of airways diseases. This study is the result of implementation of projects: "Environmental aspects of urban area" (ITMS: 26220220110) supported by the Research & Development Operational Programme funded by the ERDF; VEGA (1/0042/12).
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机译：背景：某些工作环境会极大地影响人类健康，特别是在工人暴露于有害环境和工作场所的有害物质以及有害的环境和生活方式因素的情况下。目的：由于邻苯二甲酸盐对人的潜在毒性，因此对塑料工业中受环境影响的人群进行了一项队列研究。方法：使用AQM60环境站，DustTrak DRX8533和VaisalaWXT520进行空气质量检测。从22个个体中收集尿液，使用HPLC MS / MS分析母体邻苯二甲酸酯化合物和邻苯二甲酸酯代谢物。用标准方法检查个人问卷，肺活量测定法和人体测量法。结果：在生产车间中较高水平的地方检测到了CO，NOx，SO2，CO2，VOC，PM1，PM2.5，PM10和总粉尘。检出了慢性阻塞性肺疾病（4.5％）和慢性粘膜尿管性支气管炎（50.0％）的症状。 BMI（26.8; 28.2），FMI（6.2; 11.0），FFMI（20.4; 17.21）和WHR（0.96; 0.89）的男女有增加的趋势。所有患者的尿液样本中均含有MEP-邻苯二甲酸单乙酯，MBP-邻苯二甲酸单丁酯，MEHP-邻苯二甲酸单乙基己酯和MiNP-邻苯二甲酸单异壬酯，表明广泛的邻苯二甲酸酯暴露。邻苯二甲酸二-2-乙基己酯DEHP（59μg/ kg /天）超过了每日容许摄入量（TDI）。患有气道疾病的个体中的DiNP（邻苯二甲酸二异壬酯）更高（7.24μg/ kg /天）。结论：不令人满意的工作条件（较高温度，较低相对湿度，邻苯二甲酸盐的存在）可能对人体健康产生负面影响。我们假设邻苯二甲酸盐的暴露作为气道疾病存在的致病因素的潜在影响。这项研究是实施以下项目的结果：由ERDF资助的研究与开发运营计划支持的“城市环境方面”（ITMS：26220220110）; VEGA（1/0042/12）。
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