Study of liver health hazards in pesticides sprayers and the role of antioxidants supplementation

摘要

Background: Organophosphours pesticides represent more than 80% of total pesrticides used in Egypt. Several studies detected an alteration in the liver enzymes activities among occupational workers exposed to organophosphorus pesticides alone or in combination with organochlorine. The aim of the study was estimation of the impact of occupational exposure to organophosphorus pesticides on the liver and the oxidative antioxidants balance in male pesticides spray farmers, and evaluation of the ameliorative effects of antioxidants supplementation rich in Zn. Methods: ALT, AST, GGT, SOD, GPx, zinc and MOA were estimated in 46 pesticides sprayers before and after supplementation by antioxidants rich in zinc for two month. The results revealed that the liver, as well as oxidative-antioxidant balance were affected in the pesticides sprayers, and this affection increased with the increase in the duration of exposure. Antioxidants supplementation rich in zinc for two month was found to have significant improving effects on the liver functions, as well as on the oxidative-antioxidant balance in the pesticides sprayers. Conclusion: Organophosphorus pesticides cause oxidative stress that alter the liver enzymes and the antioxidants in the pesticides sprayers, and antioxidants supplementation rich in Zn improved these hazardous effects.