Background: The Ministry of Health Biomonitoring Study measured internal exposure to bisphenol A (BPA), organophosphate pesticides (OPs), and other contaminants. However, little is known about sources of exposure to these substances in the Israeli population. Methods: From December 2010-January 2011, 250 individuals ages 20-73 were recruited from five regions in Israel. Urine samples and questionnaire data, including 24 hr dietary recall data, were obtained. Food mixtures reported were disaggregated to allow estimation of commodity intakes. Regression analyses were performed to identify risk factors for BPA and OP exposures. Results: Median creatinine adjusted urinary BPA concentrations in our population were higher than those reported for the U.S., Germany, and Canada. Median creatinine adjusted concentrations of the OP metabolites dimethyl phosphate and dimethyl thiophosphate) were higher in our population than in the U.S. and Canada, and comparable to those in France. Urinary BPA concentrations were higher in Jews than in Arabs or Druze (2.49, 0.82. and 0.89 μg/g creatinine, respectively; p = 0.02). BPA concentrations were higher in smokers, but not significantly (p = 0.055). Mushroom consumers had urinary BPA levels twice as high as nonconsumers (p = 0.03) in a multivariate analysis. Canned fish consumers had higher urinary BPA (2.36 μg/g) than nonconsumers (1.87 μg/g) but the difference was not significant. Females age ＞ 44 y had higher urinary DAP concentrations for several metabolites. Fruit and vegetable intakes ＞ 75th % were related to urinary diethyl phosphate metabolites, but not to dimethyl forms. In a multivariate model, total molar DAP levels increased with age, by a factor of 1.01 per year (p=.04), and were higher in subjects with high income compared to subjects with the lowest income by a factor of 1.59 (p=.02). Conclusions: These results will be used to formulate public health policies targeted at lowering exposures to BPA and OPs.
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