Analysis of the emergence of drug resistant HIV for drug scheduling methods

摘要

HIV/AIDS drug therapies, including highly active anti-retroviral therapy (HAART), often fail because of the emergence of drug resistant mutation. We research a new evaluation method for the possibility of the resistant emergence in this paper. We suggest a quantitative estimation method to evaluate this possibility for antiretroviral drug treatment of HIV infection. By doing so, this paper reports research on quantitative description of the emergence of drug resistant HIV for drug therapies. By means of simulation studies we compare HIV/AIDS therapies by applying the evaluation method to the therapies.