Characterization and Release Kinetics of Calcium Silicate Cement as a Risedronate Delivery System

摘要

The setting time and compressive strength results clearly demonstrate that RA modifies calcium silicate cement hydration mechanism, which is attributed to RA high affinity to calcium ions. The IR spectrum of the hardened CSC samples with 10% RA is notably different from that of pure RA or stoichiometric RA-calcium complexes implying the formation of risedronate calcium complexes in CSC, which is not a simple reaction with risedronate and Ca(OH)_2. These results indicate that progressively adsorbed onto CSH surfaces, RA is able to inhibit further growth and entanglement of CSH gels, resulting into the loss of mechanical strength. Based upon our study release profiles, CSC is capable of delivering RA in a sustained and controllable manner. CSC is thus able to double up as a slow-release drug delivery vehicle for the third generation bisphosphonate risedronate.