Tissue Engineered Human Anterior Cruciate Ligament Derived Cellular Patch for Partial ACL Repair

摘要

Our results demonstrate that hACL derived cells can be isolated and expanded, and the PLAGA patch promoted growth. This technique is a reproducible and a reliable way to provide a potential cell source for a wide array of future investigations for ACL reconstruction. Our primary direction with the hACL/2D scaffold is for the future use as a patch to augment primary repair of partial ACL tears. Our protocol would allow a combination of suture repair with a 2D scaffold that offers a delivery system for hACL derived cells into the wound site while simultaneously protecting the cells from the synovial fluid environment. This could allow functional repair and healing of a partial tear, avoiding the comorbidities associated with ACL reconstruction. This technique demonstrates promising results and future investigation will display the potential of this technique for ACL repair and reconstruction.