3D Bioprinted Constructs Laden with Iron Oxide Nanoparticles for Diverse Tissue Engineering Applications

摘要

Overall, this work demonstrates that 3D printed NP laden constructs used in tissue engineering applications can be used in prevention of biofilm formation and also as potential contrast agents in-vivo. It also suggests that difference in SPION concentrations aid in providing increases in CT/MRI constrast and antimicrobial activity. Ongoing studies are focusing on incorporating macrophages in co-culture with staph epi to elicit an immune response in-vitro. Future studies will incorporate functional cardiomyocytes into the printed NP-laden tissues and assess for cell viability and cell phenotype. This work informs on the use of nanoparticles in 3D bioprinted tissues and contribute to their potential therapeutic applications in a clinical setting.