pH-sensitive Liposomes as Drug Carriers for the Treatment of Brain Infection Diseases

摘要

All results obtained for TAT-functionalized liposomes, including their low MIC with respect to the use of free antibiotic plus their remarkable high percentage of cell viability with astrocytes and endothelial cells, provides evidence that this liposomal system can be a safe, alternative means for treating bacterial meningitis. The next steps in this research will look at more BBB studies, and the study of the effect of the liposome treatment on the genetic properties of the bacterial cell membrane, to better understand their cell uptake mechanism. This work was supported by funds from Northeastern University.