IDMA1 and IDMA2 were successfully synthesized and characterized by NMR and MS. Incorporation of IDMA1 or IDMA2 monomers into UDMA/PEG-U/EHMA matrices improved the DVC (restricting the potential of unreacted monomers from leaching-out) and did not alter the hydrophobic / hydrophilic balance of the resins. As reported with other resin matrices [2], mammalian cell lines appeared to be more sensitive than human cell lines. Cellular responses to dental materials were concentration-dependent and contingent on time of exposure. In some cases, cellular metabolic activity may have been affected, but not viability. Of the parameters commonly tested to determine cytotoxic potential, it is unknown which factors are most impacting. Further consideration will be given to analyzing existing data for ranking factors and development of a predictive model for in vitro cytotoxicity induced by dental restorative materials. We suggest that in vitro cytotoxicity evaluations become a determinant on whether multifunctional polymeric material(s) should further undergo in-depth mechanical, physiochemical, and antimicrobial studies.
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