A mechanistic study of anti-HIV activity and cancer registry match investigation in laboratory drug 2- Indolinones show record linkage among them many interesting leads evaluation

摘要

Statement of Purpose: It is well documented that HIV infection dramatically increases the risk for various cancers. However the risks for cancers overall and specifically by different types among HIV-positive individuals in India are largely unknown and it is generally felt that these risks are lower than that reported in other populations. The little that is known about the association of HIV and malignancies in India stems from case reports and hospital based studies. There have been very few cases reported of Kaposi's sarcoma and hospital based prevalence studies of HIV in cancers have found rates ranging from 1 to 4%. One hospital based study which analysed data on testing of cancer patients (Cancer Causes and Control 2008; 19; 147-153) has provided some preliminary estimates in the form of Proportional Incidence Ratios (PIRs) which confirmed the preliminary impression that Kaposi's sarcoma is rarely observed in HIV infected individuals in India. The study found increased PIRs for non-Hodgkin's lymphoma (NHL) and anal cancer in males and females, increased PIR for cervical and vaginal cancer in females and Hodgkin's disease, testicular cancer, colon cancer, and several head and neck cancer sites in men. However there have been no populations based studies to assess the risk of different cancers in HIV. It is well accepted that such studies which minimise selection, response and referral biases would be able to provide better estimates of cancer risk for different anatomical sites among HIV infected persons in a region. Systematic monitoring of cancer burden is therefore important both from a public health and from a clinical management perspective to maximize the benefits of a resource intensive intervention. Record linkage is a well-recognized tool to study the morbidity and mortality patterns in a population in general or in a particular area. Matching of HIV and Cancer registry's has been found to be a useful tool for understanding HIV and Cancer epidemiology in many developed countries of the world (USA, UK, Australia, Italy) and also in Uganda. It was felt however that this kind of a linkage study would not be possible in India due to lack of unique identification number for matching and databases (especially small molecule drug discovery part). The approach can be used in bioinformatics practices, to take this study further, a laboratory work focused on interesting finding novel lead molecule of 2- Indolinones showed such record-linkage in multiple anti cancerous and HIV-1 activity.