Hyaluronic Acid Silica Sol-gel Nano-hybrids by Biomimetic Approach

摘要

HA-silica hybrids were successfully fabricated using a biomimetic silica sol-gel process. Remarkably enhanced mechanical properties of HA-silica hybrids were achieved by an effective method that facilitates the formation of the rigid and homogeneous silica network. The mechanical strength of HA-silica hybrids can be tailored along with bioactivity by adjusting the silica contents. These findings indicate that HA-silica hybrid system would be a promising substitute for tissue engineering applications.