Magnetic Alignment of Electrospun Poly-1 lactic acid Fibers for Directed Cell Guidance after Spinal Cord Injury

摘要

Conclusions: To our knowledge, this is the first time that an injectable hydrogel-electrospun fiber composite scaffold has been proposed for treatment of SCI. This preliminary work optimizes magnetic fibers for alignment in situ. The 6% SPION fibers display the greatest magnetic movement without requiring significant electrospinning modification. . This innovative approach will ultimately enable the incorporation of topographical guidance cues into an injectable scaffold. Future work focuses on applying this approach to a SCI animal model.