Design of a Drug Eluting Stent for treatment of pancreatic malignancy

摘要

The present study shows the possibility to achieve polymeric coating on metallic stents and to optimize the interface properties. By changing processing conditions it is possible to modulate thickness of the film layer. The proposed system allows, besides, the possibility to release suitable drugs from the coating. Preliminary studies in this direction are in progress. Upon identification of the ideal controlled release formulation a cohort of mice with PDAC-6 xenografts will be evaluated for adjunctive treatment based on optimal tumor/normal tissue toxicity that may enhance local therapy delivery. These initial studies will provide the foundation for the development of viable local delivery platforms to treat pancreatic cancer.