Antigen-Specific Immune Response of Microparticle Vaccine Containing CpG-ODN and Protein

摘要

Microparticles co-encapulating CpG and a model protein OVA enhance the antigen-specific Th1-biased immune response. The improved efficacy is attributed to increased uptake of microparticles by APCs and the Th1 -polarizing influence of CpG, suggesting a potential formulation for vaccines requiring a CD8~+ cyto-toxic immune response. Our further research will focus on testing efficacy of this vaccine formulation using antigen proteins, such as NH36 for Leishmania and Tc24 for Chagas disease.